Basic Information
| LncRNA/CircRNA Name | circCDR1as |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR |
| Sample | gastric cancer tissues an cell lines |
| Expression Pattern | differential expressed |
| Function Description | high-dose DB (50?M) significantly decreased CircRNA CDR1as levels in gastric cancer cells instead of hepatocytes. Notably, knock-down of CircRNA CDR1as triggered low-dose DB (12.5?M) induced GC cell death, but had little effects on hepatocytes proliferation and apoptosis. |
| Pubmed ID | 31542615 |
| Year | 2019 |
| Title | Downregulation of CircRNA CDR1as Specifically Triggered Low-Dose Diosbulbin-B Induced Gastric Cancer Cell Death by Regulating miR-7-5p/REG? Axis |
External Links
| Links for circCDR1as | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |