Basic Information
| LncRNA/CircRNA Name | circDENND4C |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR |
| Sample | breast cancer cell lines |
| Expression Pattern | up-regulated |
| Function Description | circDENND4C highly expressed in breast cancer was up-regulated in response to hypoxia. Knockdown of circDENND4C decreased glycolysis, migration and invasion in breast cancer cells under hypoxia. circDENND4C was validated as a sponge of miR-200b and miR-200c. |
| Pubmed ID | 31488193 |
| Year | 2019 |
| Title | Knockdown of circDENND4C Inhibits Glycolysis, Migration and Invasion by Up-Regulating miR-200b/c in Breast Cancer Under Hypoxia |
External Links
| Links for circDENND4C | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |