Basic Information
| LncRNA/CircRNA Name | circ_000926 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR |
| Sample | renal cell carcinoma?tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | irc_000926 was highly expressed in RCC tissues and cell lines, whereas CDH2 was verified to be a target of miR-411. As a competing endogenous RNA, circ_000926 could directly bind to miR-411 to up-regulate CDH2. Down-regulation of circ_000926 resulted in inhibited growth, migration, and invasion abilities of RCC cells, as well as suppressed epithelial-mesenchymal transition and tumor growth. |
| Pubmed ID | 31476285 |
| Year | 2019 |
| Title | Down-Regulation of Circular RNA_000926 Attenuates Renal Cell Carcinoma Progression Through miRNA-411-Dependent CDH2 Inhibition |
External Links
| Links for circ_000926 | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |