Basic Information
| LncRNA/CircRNA Name | circSCAF11 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, CCK-8 |
| Sample | glioma tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | circSCAF11 expression was found to be significantly upregulated in the glioma tissue specimens and cell lines. The ectopic overexpression of circSCAF11 was closely correlated with the poor clinical outcome of glioma patients. Functionally, knockdown of circSCAF11 inhibited the proliferation, invasion, and tumor growth and induced the G0/G1 phase arrest. |
| Pubmed ID | 31400609 |
| Year | 2019 |
| Title | Circular RNA circSCAF11 Accelerates the Glioma Tumorigenesis Through the miR-421/SP1/VEGFA Axis |
External Links
| Links for circSCAF11 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |