Basic Information
| LncRNA/CircRNA Name | circLRP6 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | osteosarcoma tissues |
| Expression Pattern | up-regulated |
| Function Description | CircLRP6 level markedly increased in OS tissues. Besides, OS patients with high expression of circLRP6 showed shorter disease-free survival and over-all survival than those with low expression. CircLRP6 knockdown suppressed proliferative, migratory and invasive rates of OS cells. Moreover, circLRP6 knockdown induced apoptosis and arrested cell cycle in G0/G1 phase. |
| Pubmed ID | 31396323 |
| Year | 2019 |
| Title | CircRNA LRP6 Promotes the Development of Osteosarcoma via Negatively Regulating KLF2 and APC Levels |
External Links
| Links for circLRP6 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |