Basic Information
| LncRNA/CircRNA Name | circIGF1R |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR |
| Sample | liver cancer tissues and celll lines |
| Expression Pattern | up-regulated |
| Function Description | Circ-IGF1R levels were found to be significantly upregulated in HCC tissues compared with levels in paired peritumoural tissues. The high expression levels of circ-IGF1R in HCC were associated with tumour size. Moreover, knocking down circ-IGF1R with siRNA significantly attenuated cell proliferation and induced cell apoptosis and cell cycle arrest in vitro. |
| Pubmed ID | 31377314 |
| Year | 2019 |
| Title | Circ-IGF1R Has Pro-Proliferative and Anti-Apoptotic Effects in HCC by Activating the PI3K/AKT Pathway |
External Links
| Links for circIGF1R | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |