Basic Information
| LncRNA/CircRNA Name | circPTPRZ1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blotting , luciferase reporter assay , cell proliferation , flow cytometric , and transwell assays |
| Sample | human glioblastoma cell lines (A172 and LN229) |
| Expression Pattern | NA |
| Function Description | Studies on circRNAs in glioma cells revealed that miR-1261 had almost completely matched binding site on the circ-PTPRZ1 sequence, and circ-PTPRZ1 was a target gene of miR-1261. MiR-1261 inhibited circ-PTPRZ1 expression in glioma cells, while circ-PTPRZ1 did not affect miR-1261 expression. At the same time, circ-PTPRZ1 could promote p-PAK1 expression, while miR-1261 suppressed the activation of PAK1 by regulating the expression of circ-PTPRZ1.circ-PTPRZ1 enhanced cell proliferation and invasion, and inhibited cell apoptosis; miR-1261 had the opposite effects, and could terminate the above effects of circ-PTPRZ1. When co-transfected with PAK1 siRNAs and circ-PTPRZ1 over-expression vector, the changes of above biological behaviors were not obvious. |
| Pubmed ID | 31364003 |
| Year | 2019 |
| Title | MiR-1261/circ-PTPRZ1/PAK1 Pathway Regulates Glioma Cell Growth and Invasion |
External Links
| Links for circPTPRZ1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |