Basic Information
| LncRNA/CircRNA Name | circ_0007142 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR , luciferase assay , cell proliferation assay , colony formation assay , cell migration and invasion assay |
| Sample | CRC and adjacent paracancerous tissues ,human colorectal cancer cells (HCT-116, HT-29, and LoVo )and normal human enteral epithelial (HCO) cells |
| Expression Pattern | up-regulated |
| Function Description | Using a circRNA microarray, we identified 892 differentially expressed circRNAs between six pairs of CRC and adjacent paracancerous tissues. Among them, hsa_circ_0007142 was significantly upregulated. hsa_circ_0007142 upregulation was associated with poor differentiation and lymphatic metastasis of CRC. hsa_circ_0007142 targeted miR-103a-2-5p in CRC cells. Moreover, the silencing of hsa_circ_0007142 by siRNAs decreased the proliferation, migration, and invasion of HT-29 and HCT-116 cells. |
| Pubmed ID | 31346335 |
| Year | 2019 |
| Title | Circular RNA hsa_circ_0007142 Is Upregulated and Targets miR-103a-2-5p in Colorectal Cancer |
External Links
| Links for circ_0007142 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |