Basic Information
LncRNA/CircRNA Name | circ_0008450 |
Synonyms | |
Region | |
Ensemble | |
Refseq |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | apoptosis | Drug | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | nasopharyngeal cancer |
ICD-0-3 | C11 |
Methods | qRT-PCR , Western blotting , CCK-8 assay , wound healing assays , transwell experiments , Dual luciferase reporter assays |
Sample | NPC tissues and paired adjacent non-tumor tissues ,NPC cells(HK-1, 5-8F, C666-1, and SUNE-1) and NP69 cells |
Expression Pattern | up-regulated |
Function Description | The results showed that circ_0008450 was elevated in NPC tissues and cells. Silenced circ_0008450 could inhibit cell proliferation, and metastatic properties and increased the number of apoptotic cells. Ectopically expressed circ_0008450 strengthened the abovementioned malignant biological behaviors. Mechanistically, circ_0008450 reduced miR-577-mediated repression of CXCL9, resulting in facilitating the oncogenic functions of NPC. |
Pubmed ID | 31344361 |
Year | 2019 |
Title | Circular RNA circ_0008450 Upregulates CXCL9 Expression by Targeting miR-577 to Regulate Cell Proliferation and Invasion in Nasopharyngeal Carcinoma |
External Links
Links for circ_0008450 | GenBank HGNC NONCODE |
Links for nasopharyngeal cancer | OMIM COSMIC |