Basic Information
| LncRNA/CircRNA Name | circTP63 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung squamous cell carcinoma |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Western blotting , Luciferase activity assays , RIP , RNase R treatment , Actinomycin D assay , CCK-8 assay and cell cycle analysis |
| Sample | NSCC tissues and adjacent nontumorous tissues ,human LUSC cells (NCI-H2170, NCI-H1703, NCI-H226, NCI-H520, SW900, SK-MES-1, BEAS-2B, and HFL-1) |
| Expression Pattern | up-regulated |
| Function Description | CircTP63, is upregulated in LUSC tissues and its upregulation is correlated with larger tumor size and higher TNM stage in LUSC patients. Elevated circTP63 promotes cell proliferation both in vitro and in vivo. Mechanistically, circTP63 shares miRNA response elements with FOXM1. circTP63 competitively binds to miR-873-3p and prevents miR-873-3p to decrease the level of FOXM1, which upregulates CENPA and CENPB, and finally facilitates cell cycle progression. |
| Pubmed ID | 31324812 |
| Year | 2019 |
| Title | circTP63 Functions as a ceRNA to Promote Lung Squamous Cell Carcinoma Progression by Upregulating FOXM1 |
External Links
| Links for circTP63 | GenBank HGNC NONCODE |
| Links for lung squamous cell carcinoma | OMIM COSMIC |