Basic Information
| LncRNA/CircRNA Name | circRHOT1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , northern blotting , RNA-seq , xenograft assays , cell proliferation assay , transwell assays , chromatin immunoprecipitation , electrophoretic mobility shift , pulldown and mass spectrometry , minigene assay |
| Sample | HCC tissues and adjacent normal tissues?,primary HCC cell |
| Expression Pattern | up-regulated |
| Function Description | We identified circRHOT1 (hsa_circRNA_102034) as a conserved and dramatically upregulated circRNA in HCC tissues. HCC patients displaying high circRHOT1 level possessed poor prognosis. Through in vitro and in vivo experiments, we demonstrated circRHOT1 significantly promoted HCC growth and metastasis. Regarding the mechanism, we conducted a RNA pulldown with a biotin-labeled circRHOT1-specific probe and found that circRHOT1 recruited TIP60 to the NR2F6 promoter and initiated NR2F6 transcription. Moreover, NR2F6 knockout inhibited growth, migration and invasion, whereas rescuing NR2F6 in circRHOT1-knockout HCC cells rescued the proliferation and metastasis abilities of HCC cells. |
| Pubmed ID | 31324186 |
| Year | 2019 |
| Title | Circular RNA circRHOT1 Promotes Hepatocellular Carcinoma Progression by Initiation of NR2F6 Expression |
External Links
| Links for circRHOT1 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |