Basic Information
| LncRNA/CircRNA Name | circ_103809 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in situ hybridization , cell proliferation assay , cell cycle assay , cell migration assay , RNA pull down |
| Sample | HCC tissues and paired normal adjacent tissues ,human normal hepatocyte (LO2) and several HCC cell lines(MHCC97L, Huh7, SK??EP??, Hep3B, and HCCLM3) |
| Expression Pattern | up-regulated |
| Function Description | Our results suggested that hsa_circRNA_103809 was overexpressed in HCC patients, and hsa_circRNA_103809 knockdown remarkably inhibited the proliferation, cycle progression, and migration of HCC cells. The investigations of molecular showed that hsa_circRNA_103809 could elevate the protein expression of a miR-377-3p target, fibroblast growth factor receptor 1 (FGFR1), through interacting with miR-377-3p and decreasing its expression level. Additionally, in vivo assays revealed hsa_circRNA_103809 short hairpin RNA served as a tumor suppressor through downregulating FGFR1 in HCC. |
| Pubmed ID | 31317555 |
| Year | 2019 |
| Title | Circular RNA hsa_circRNA_103809 Promoted Hepatocellular Carcinoma Development by Regulating miR-377-3p/FGFR1/ERK Axis |
External Links
| Links for circ_103809 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |