Basic Information
| LncRNA/CircRNA Name | circHIPK3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | chronic myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qRT-PCR , western blot , luciferase reporter gene assay , cell proliferation assays , cell apoptosis assay |
| Sample | peripheral blood samples ,peripheral blood mononuclear cells (PBMC) ,human cell line 1D3 and CML cell lines (K562, KCL22, AR230-r, LAMA84-s and Kasumi-4) |
| Expression Pattern | up-regulated |
| Function Description | We found that circHIPK3 was significantly upregulated in peripheral blood mononuclear cells (PBMC) and serum samples from CML compared with healthy controls. High circHIPK3 expression predicted a poor outcome of CML patients. Further loss-function experiments suggested the oncogenic role of circHIPK3 in CML. |
| Pubmed ID | 31307197 |
| Year | 2019 |
| Title | Circular RNA circHIPK3 Serves as a Prognostic Marker to Promote Chronic Myeloid Leukemia Progression |
External Links
| Links for circHIPK3 | GenBank HGNC NONCODE |
| Links for chronic myeloid leukemia | OMIM COSMIC |