Basic Information
| LncRNA/CircRNA Name | circCRIM1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , luciferase reporter assay , western blot , RNA-seq , RIP , Microarray and CISH , fluorescence in situ hybridization , cell migration and invasion assays , in vivo metastasis assays , Real-time cell analysis |
| Sample | lung adenocarcinoma tissues and paired peripheral normal lung tissues ,human LUAC cell lines(A549, H1299, H2228, pc9, and H1975) |
| Expression Pattern | down-regulated |
| Function Description | Based on circBase data and our biobank tissues, we identified circCRIM1 as having a significantly decreased expression in LUAC samples compared with matched normal control samples. Both in vivo and in vitro experiments revealed that circCRIM1 suppresses the invasion and metastasis of LUAC.Mechanistically, we found that circCRIM1 could promote the expression of leukemia inhibitory factor receptor, a well-known tumor suppressor, by sponging miR-93 and miR-182.In the clinical and pathological analyses, the downregulation of circCRIM1 in LUAC was significantly correlated with lymphatic metastasis and TNM stage, which served as an independent risk factor for the overall survival of patients with LUAC. |
| Pubmed ID | 31301086 |
| Year | 2019 |
| Title | Circular RNA circCRIM1 Inhibits Invasion and Metastasis in Lung Adenocarcinoma Through the microRNA (miR)-182/miR-93-leukemia Inhibitory Factor Receptor Pathway |
External Links
| Links for circCRIM1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |