Basic Information
| LncRNA/CircRNA Name | circSMAD7 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR , western blot , CCK-8 Assay , cell proliferation assay , colony formation assay , wound healing assay , transwell assay, and matrigel assay |
| Sample | ovarian cancer tissues and corresponding normal tissues ,human ovarian cancer cell lines (A2780,TOV112D, OVCAR-3, and SKOV3) and the normal ovarian cell line (ISOE80) |
| Expression Pattern | up-regulated |
| Function Description | Circ-SMAD7 expression was remarkably higher in ovarian cancer tissue samples than in corresponding normal tissues. The proliferation of the ovarian cancer cells was significantly inhibited after circ-SMAD7 downregulation. Meanwhile, the migration and invasion of ovarian cancer cells were significantly inhibited after circ-SMAD7 downregulation in vitro. Both the mRNA and the protein expressions of the Kr?ppel-like factor 6 (KLF6) were remarkably promoted after circ-SMAD7 was knocked down in ovarian cancer cells. Furthermore, the KLF6 expression level was negatively correlated with circ-SMAD7 expression level in ovarian cancer samples |
| Pubmed ID | 31298312 |
| Year | 2019 |
| Title | Circular RNA circ-SMAD7 Promoted Ovarian Cancer Cell Proliferation and Metastasis by Suppressing KLF6 |
External Links
| Links for circSMAD7 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |