Basic Information
| LncRNA/CircRNA Name | circ_100533 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qRT-PCR , luciferase reporter assay , western blot , RIP , RNase R digestion , sanger sequencing , immunohistochemistry , cell proliferation assay , colony formation assay , cell migration assays , flow cytometric annexin V/PI apoptosis |
| Sample | OSCC tissues and the paired para-carcinoma tissues ,OSCC cell lines (HSC??, SCC??, SCC??5, CAL??7, and Ca9??2) |
| Expression Pattern | down-regulated |
| Function Description | circRNA microarrays and quantitative real-time polymerase chain reaction was used to identify the hsa_circRNA_100533 downregulated in OSCC tissues and cell lines. We found that hsa_circRNA_100533 binds to miRNAs as a miRNA sponge. hsa_circRNA_100533 inhibited cell proliferation, migration, and promoted cell apoptosis in OSCC cell lines, which could be blocked by hsa-miR-933 overexpression. hsa_circRNA_100533 binds to hsa-miR-933 as a miRNA sponge to regulate GNAS expression, and to modulate cell proliferation, migration, and apoptosis. |
| Pubmed ID | 31297884 |
| Year | 2019 |
| Title | hsa_circRNA_100533 Regulates GNAS by Sponging hsa_miR_933 to Prevent Oral Squamous Cell Carcinoma |
External Links
| Links for circ_100533 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |