Basic Information
| LncRNA/CircRNA Name | circZKSCAN1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | RT-PCR , RIP , fluorescence in situ hybridization , in situ hybridization |
| Sample | HCC and paired para-cancerous tissues ,HCC SMMC7721 cells |
| Expression Pattern | down-regulated |
| Function Description | The absence of circZKSCAN1 endowed several malignant properties including cancer stemness and tightly correlated with worse overall and recurrence-free survival rate in HCC. circZKSCAN1 exerted its inhibitive role by competitively binding FMRP, therefore, block the binding between FMRP and ?-catenin-binding protein-cell cycle and apoptosis regulator 1 (CCAR1) mRNA, and subsequently restrain the transcriptional activity of Wnt signaling. In addition, RNA-splicing protein Quaking 5 was found downregulated in HCC tissues and responsible for the reduction of circZKSCAN1. |
| Pubmed ID | 31281495 |
| Year | 2019 |
| Title | Circular RNAs Negatively Regulate Cancer Stem Cells by Physically Binding FMRP Against CCAR1 Complex in Hepatocellular Carcinoma |
External Links
| Links for circZKSCAN1 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |