Basic Information
| LncRNA/CircRNA Name | circNOTCH1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , luciferase activity assay , western blot , cell apoptosis assay , cell invasion assay |
| Sample | GC tissues and adjacent normal tissues ,human gastric epithelial cell line GES-1 and six GC cell lines (BGC-823,MGC-803, HGC-27, MKN-45, AGS and SGC-7901) |
| Expression Pattern | up-regulated |
| Function Description | Circ-NOTCH1 and Apelin are highly expressed in GC cells and tissues, whereas the expression of miR-637 is reduced. Circ-NOTCH1 and miR-637 do not regulate each other's expression levels, but circ-NOTCH1significantly upregulates the expression of the miR-637 target gene Apelin, whereas miR-637 inhibites the expression of Apelin.Examination of GC cells showed that circ-NOTCH1 enhances cell proliferation and invasiveness, and reduces cell apoptosis; these effects were reversed by miR-637, which could terminate the above effects of circ-NOTCH1. When co-transfected with the circ-NOTCH1 overexpression plasmid and Apelin siRNAs, there were no obvious changes to the levels of cell proliferation, apoptosis, or invasiveness. |
| Pubmed ID | 31276627 |
| Year | 2019 |
| Title | circ-NOTCH1 Acts as a Sponge of miR-637 and Affects the Expression of Its Target Gene Apelin to Regulate Gastric Cancer Cell Growth |
External Links
| Links for circNOTCH1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |