Basic Information
| LncRNA/CircRNA Name | circLgr4 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RT-PCR , circRNA knockdown , IHC , ISH and FISH , transwell invasion assay , in vivo xenograft experiments , peptide coding detection |
| Sample | 293T cells |
| Expression Pattern | up-regulated |
| Function Description | Here we identified circLgr4 as a highly expressed circRNA in colorectal tumors and colorectal CSCs. circLgr4 knockdown inhibited colorectal CSC self-renewal, colorectal tumorigenesis and invasion, and circLgr4 overexpression played opposite roles. With peptide-coding capacity, circLgr4 drove the self-renewal of colorectal CSCs through peptide-dependent manner. circLgr4-derived peptide interacted with and activated Lgr4, which further promoted the activation of Wnt/?-catenin signaling. circLgr4-peptide-Lgr4 axis could be used to target colorectal CSCs and colorectal tumorigenesis. |
| Pubmed ID | 31269234 |
| Year | 2019 |
| Title | circLgr4 Drives Colorectal Tumorigenesis and Invasion Through Lgr4-targeting Peptide |
External Links
| Links for circLgr4 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |