Basic Information
| LncRNA/CircRNA Name | circ_0000745 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR , circRNA Microarray , western blot , cell viability assay and apoptosis assay , cell migration and invasion assay |
| Sample | CC tissues and adjacent nontumorous cervical tissues ,cells(SiHa and CaSki) |
| Expression Pattern | up-regulated |
| Function Description | hsa_circ_0000745 was upregulated in CC, and its level positively correlated with the level of its linear messenger RNA isoform. Patients with poorly differentiated tumors or vascular/lymphatic invasion presented higher expression of hsa_circ_0000745. The role of hsa_circ_0000745 was illuminated by knocking down hsa_circ_0000745 in CC cells, and the results revealed that reducing hsa_circ_0000745 inhibited cell proliferation, migration, and invasion in CC by upregulating E-cadherin (E-cad) expression. |
| Pubmed ID | 31256433 |
| Year | 2019 |
| Title | hsa_circ_0000745 Promotes Cervical Cancer by Increasing Cell Proliferation, Migration, and Invasion |
External Links
| Links for circ_0000745 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |