Basic Information
| LncRNA/CircRNA Name | circDCAF6 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , Dual luciferase reporter assay , cell growth determination , cell apoptosis assay , transwell experiment |
| Sample | GC tissues and matched noncancerous tissues,GC cells(AGS, BGC823, MGC803, and SGC7901)and control cells (GES1) |
| Expression Pattern | up-regulated |
| Function Description | Upregulation of circ-DCAF6 was determined in GC tissue samples and cells by qRT-PCR. Enhanced level of circ-DCAF6 was linked to deeper tumor invasion, positive lymph node metastasis, and higher TNM stages in GC patients.Multivariate analysis further indicated circ-DCAF6 as an independent prognostic indicator. Functionally, CCK-8, clone forming, flow cytometry and transwell assays verified that circ-DCAF6 played as an oncogene in GC cells. Mechanistically, we found the negative correlation between circ-DCAF6 and miR-1231/-1256 in GC specimens. Moreover, luciferase reporter gene assay illustrated that miR-1231 and miR-1256 could be bound to circ-DCAF6. Rescue experiments revealed that circ-DCAF6 facilitated cell growth and invasion via suppressing the levels of miR-1231 and miR-1256. |
| Pubmed ID | 31226266 |
| Year | 2019 |
| Title | Enhanced Expression of Circular RNA circ-DCAF6 Predicts Adverse Prognosis and Promotes Cell Progression via Sponging miR-1231 and miR-1256 in Gastric Cancer |
External Links
| Links for circDCAF6 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |