Basic Information
| LncRNA/CircRNA Name | circRAD23B |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qRT-PCR , luciferase assay , western blot , transwell |
| Sample | esophageal cancer specimens and adjacent tissues ,peripheral blood mononuclear cell (PBMC) ,human normal esophageal epithelial cell line HEEC ,human esophageal cancer cell lines(EC109, KYSE-150, TE-1 and TE-10),human gastric cancer cell line HGC-27, human hepatocarcinoma cell line HepG2, human breast cancer cell line MDA-MB-231 and human embryonic kidney cell line HEK-293T |
| Expression Pattern | up-regulated |
| Function Description | In the present study, we found that circular RNA-RAD23B (circRAD23B) was upregulated in specimens of patients with esophageal cancer. Further investigation revealed that circRAD23B promoted proliferation and invasion of esophageal cancer cells. Next, we identified microRNA-5095 (miR-5095) as a target of circRAD23B, and found that miR-5095 was negatively correlated to the expression of circRAD23B in esophageal cancer. In addition, circRAD23B facilitated expression of PARP2 and AKT2 by sponging miR-5095, which might underlie the growth of esophageal cancer. |
| Pubmed ID | 31208717 |
| Year | 2019 |
| Title | CircRAD23B Facilitates Proliferation and Invasion of Esophageal Cancer Cells by Sponging miR-5095 |
External Links
| Links for circRAD23B | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |