Basic Information
| LncRNA/CircRNA Name | circ_0091570 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , luciferase reporter assay , RIP , western blot , RNase R digestion , sanger sequencing , cell cycle assay , apoptotic assay , cell proliferation assay , colony formation assay , wound healing assay , cell migration and invasion assays , metastasis assays , immunohistochemistry |
| Sample | HCC tissues and matched para-carcinoma normal tissues ,human HCC cell lines (HepG2 and SMMC-7721) and normal liver cell lines (LO2) |
| Expression Pattern | down-regulated |
| Function Description | The decreased expression of hsa_circ_0091570 was associated with the pathological staging of HCC patients. Furthermore, inhibition of hsa_circ_0091570 promoted cell proliferation and migration, blocked cell apoptosis in HCC cell lines, and promoted tumor growth in the mouse xenograft model. RNA immunoprecipitation assay verified the interaction of hsa_circ_0091570 and miR-1307. The miR-1307 inhibitor inhibited the function induced by hsa_circ_0091570 siRNA. |
| Pubmed ID | 31207319 |
| Year | 2019 |
| Title | hsa_circ_0091570 Acts as a ceRNA to Suppress Hepatocellular Cancer Progression by Sponging hsa-miR-1307 |
External Links
| Links for circ_0091570 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |