Basic Information
| LncRNA/CircRNA Name | circ_0001206 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qRT-PCR , Dual luciferase reporter assay , western blot , cell viability assessment , cell migration and invasion assays , GEPIA |
| Sample | PCa tissues and adjacent normal tissues ,cell lines(RWPE-1, PC-3, DU145, and LNCaP) |
| Expression Pattern | down-regulated |
| Function Description | hsa_circ_0001206, hsa_circ_0001633, and hsa_circ_0009061 were validated to be down-regulated in PCa and hsa_circ_0001206 as well as hsa_circ_0009061 was significantly associated with clinical features of PCa patients.The down-regulation of hsa_circ_001206 was partly because of the regulation of DExH-Box Helicase 9 (DHX9). Moreover, overexpression of hsa_circ_0001206 inhibited PCa cell proliferation, migration, and invasion in vitro and prevented tumor growth in vivo.Dual-luciferase reporter assays showed hsa_circ_0001206 could directly bind to miR-1285-5p. The expression of Smad4, a well-known suppressive gene in PCa, can be increased by overexpression of hsa_circ_0001206 and this effect could be partly reversed by co-transfection of miR-1285-5p mimic. |
| Pubmed ID | 31198063 |
| Year | 2019 |
| Title | Hsa_Circ_0001206 Is Downregulated and Inhibits Cell Proliferation, Migration and Invasion in Prostate Cancer |
External Links
| Links for circ_0001206 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |