Basic Information
| LncRNA/CircRNA Name | CCAT1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000247844 |
| Refseq | NR_108049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | prostate cancer tissues, cell lines (PC-3) |
| Expression Pattern | up-regulated |
| Function Description | CCAT1 was increased in prostate cancer specimen as com-pared to the adjacent areas. Increased CCAT1 was significantly related to lymph node metastasis in prostate cancer. Low-expression of CCAT1 could suppress cell proliferation. Knockdown of CCAT1 inhibited the migration of PC-3 cells. Down-regulation of CCAT1 attenuated the invasion of PC-3 cells. |
| Pubmed ID | 29863242 |
| Year | 2018 |
| Title | Long Non-Coding RNA CCAT1 Promotes the Migration and Invasion of Prostate Cancer PC-3 Cells |
External Links
| Links for CCAT1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |