Basic Information
| LncRNA/CircRNA Name | circCDR1as |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR , western blot , MTT assay , scratch-wound assay , transwell assay , CCK8 assay , immunofluorescence assay |
| Sample | ovarian tissues ,ovarian epithelial tissues ,ovarian cancer cell lines(HO8910 and A2780) |
| Expression Pattern | down-regulated |
| Function Description | CDR1as expression in ovarian tissues was significantly lower in ovarian cancer patients than in patients without ovarian cancer. CDR1as overexpression inhibited the proliferation, invasion and migration of ovarian cancer cells. Silencing CDR1as increased the expression of miR-135b-5p and decreased the expression of hypoxia-inducible factor 1-alpha inhibitor (HIF1AN), thus increasing the proliferation capacity of ovarian cancer cells. |
| Pubmed ID | 31190886 |
| Year | 2019 |
| Title | Circular RNA CDR1as Acts as a Sponge of miR-135b-5p to Suppress Ovarian Cancer Progression |
External Links
| Links for circCDR1as | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |