Basic Information
| LncRNA/CircRNA Name | circPCMTD1 |
| Synonyms | circ_0001801 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Dual luciferase reporter assay , RIP , cell proliferation assay , cell migration assay , cell invasion assay , flow cytometry (FCM) assay , nude mouse tumorigenicity assay |
| Sample | Glioma cell lines( U251 and U118MG, and HEK-293T cells) |
| Expression Pattern | up-regulated |
| Function Description | In this study, circPCMTD1 upregulation promoted the cell viability, migration and invasion dramatically, while the inhibition of circPCMTD1 led to a significant reduction of tumor growth in vivo. CircPCMTD1 knockdown could upregulate the expression of miR-224-5p and downregulate the expression of mTOR, one of miR-224-5p targets, in both cell lines. there was a complementary sequence in circPCMTD1 for miR-224-5p.circPCMTD1 were targets of miR-224-5p. Overexpression of miR-224-5p inhibited the viability and proliferation, migration, and invasion of U251 and U118MG glioma cells. |
| Pubmed ID | 31179240 |
| Year | 2019 |
| Title | CircPCMTD1 Acts as the Sponge of miR-224-5p to Promote Glioma Progression |
External Links
| Links for circPCMTD1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |