Basic Information
| LncRNA/CircRNA Name | circ0047905 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , western blot , Microarray , in situ hybridization assay |
| Sample | GC tissues and paired adjacent noncancerous mucosal tissues ,293T cell and human GC cell line AGS |
| Expression Pattern | up-regulated |
| Function Description | In a previous study, we observed both circRNA0047905 and SERPINB5 mRNA were up-regulated in GC tissues and our data supported the notion that there was a significantly positive correlation between circRNA0047905 and SERPINB5 mRNA in GC tissues.Mechanistically, we demonstrated that circRNA0047905 directly binds miR4516 and miR1227-5p, relieving suppression for targets SERPINB5 and MMP11. We observed that down-regulated circRNA0047905 expression in gastric cancer cells inhibited Akt/CREB signaling pathway activation. |
| Pubmed ID | 31157588 |
| Year | 2019 |
| Title | Circular RNA 0047905 Acts as a Sponge for microRNA4516 and microRNA1227-5p, Initiating Gastric Cancer Progression |
External Links
| Links for circ0047905 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |