Basic Information
| LncRNA/CircRNA Name | circ_0020123 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Dual luciferase reporter assay , cell growth detection , cell apoptosis assay , immunoblotting assay , cell migration and invasion assay |
| Sample | NSCLC tissues and adjacent normal tissues ,human bronchial epithelial cells (16HBE) and NSCLC cells(H1299, H1581, H358, and A549) |
| Expression Pattern | up-regulated |
| Function Description | The results revealed elevation of circ_0020123 in tissue specimens and cells than the nontumorous tissues and 16HBE, separately. The enhancement of circ_0020123 in tumor tissues correlated with positive lymph node metastasis, advanced TNM stages, and adverse prognosis for NSCLC patients. Functionally, silencing of circ_0020123 distinctly suppressed the growth, migration and invasion and inhibited the apoptosis of A549 cells. For the mechanism exploration, circ_0020123 could sponge miR-488-3p to release its inhibition on ADAM9 expression. |
| Pubmed ID | 31153639 |
| Year | 2019 |
| Title | Circular RNA circ_0020123 Promotes Non-Small Cell Lung Cancer Progression by Acting as a ceRNA for miR-488-3p to Regulate ADAM9 Expression |
External Links
| Links for circ_0020123 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |