Basic Information
| LncRNA/CircRNA Name | CCAT1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000247844 |
| Refseq | NR_108049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot etc |
| Sample | NSCLC and matched tumor-adjacent tissues, cell lines (A549, H1299, H1975 and HCC827) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA-CCAT1 was upregulated in NSCLC tissues. High expression of lncRNA-CCAT1 was related to tumor growth and reduced survival rate. microRNA-218 (miR-218) was confirmed as an effective target of lncRNA-CCAT1 in NSCLC. |
| Pubmed ID | 32323859 |
| Year | 2020 |
| Title | Long non-coding RNA CCAT1 enhances human non-small cell lung cancer growth through downregulation of microRNA-218 |
External Links
| Links for CCAT1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |