Basic Information
| LncRNA/CircRNA Name | circ_0001649 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Dual luciferase reporter assay , western blot , RIP , RNase R digestion , sanger sequence , cell proliferation assay , colony formation assay , cell migration assay , RNA pull-down assay , immunohistochemical staining , tumourigenicity assay |
| Sample | HCC and paired adjacent nonmalignant tissues ,cell lines(HHCC, H-97, HepG2, HuH-7, Li-7, SMMC-7721, HepG2.2.15 and HL-7702 cell lines) |
| Expression Pattern | down-regulated |
| Function Description | Results showed that circ-0001649 was markedly decreased in hepatocellular carcinoma cell lines and tumor tissues. Overexpression of circ-0001649 greatly inhibited proliferation and migration of HCC in vitro and in vivo. More importantly, we confirmed that circ-0001649 regulated cellular behaviors of HCC cells by targeting SHPRH. Furthermore, we determined that circ-0001649 served as a ceRNA to sponge miR-127-5p, miR-612 and miR-4688, thus activating SHPRH. |
| Pubmed ID | 31137016 |
| Year | 2019 |
| Title | Circular RNA hsa_circ_0001649 Inhibits Hepatocellular Carcinoma Progression?via?Multiple miRNAs Sponge |
External Links
| Links for circ_0001649 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |