Basic Information
| LncRNA/CircRNA Name | circZNF264 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , western blot , Dual luciferase assay , cell proliferation assays , flow cytometric assay , transwell matrigel invasion assay |
| Sample | human normal astrocytes and U251 glioma cells and glioma cell lines (LN18, A172,T98G, and LN229) |
| Expression Pattern | up-regulated |
| Function Description | Detection of circRNAs in glioma cells revealed that the expression of circ-ZNF264 was upregulated. At the same time, the expression of miR-4493 was downregulated in glioma cells and had multiple binding sites on the circ-ZNF264 sequence.MiR-4493 could bind to circ-ZNF264 and apelin specifically.MiR-4493 expression was not changed, but its target gene apelin expression could be significantly upregulated by circ-ZNF264.MiR-4493 could inhibit the expression of circ-ZNF264 and apelin.circ-ZNF264 promoted cell proliferation and invasion and inhibited apoptosis. MiR-4493 had the opposite effects and could terminate the above effects of circ-ZNF264. When the expression of apelin was downregulated and that of circ-ZNF264 was upregulated, the changes of the above biological behaviors were not obvious. |
| Pubmed ID | 31114952 |
| Year | 2019 |
| Title | Circ-ZNF264 Promotes the Growth of Glioma Cells by Upregulating the Expression of miR-4493 Target Gene Apelin |
External Links
| Links for circZNF264 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |