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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	NA	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	colorectal cancer
ICD-0-3	C19.9
Methods	qRT-PCR , western blot , luciferase reporter assay , RIP , IHC , FISH , RNase R resistance , CCK8 proliferation assay , wound healing assay , transwell invasion assay
Sample	colorectal cancer and corresponding paracancerous tissues ,human normal colonic epithelial cells (NCM460) and CRC cell lines (HT29,SW480, HCT-116, SW620, Lovo, SW48, DLD-1, Caco-2 and HCT-15)
Expression Pattern	down-regulated
Function Description	Hsa_circ_0009361 was significantly down-regulated in CRC tissues and cells. Low expression level of hsa_circ_0009361 promoted the proliferation, epithelial-mesenchymal transition (EMT), migration, and invasion of CRC cells. Hsa_circ_0009361 was identified as the sponge of miR-582. Overexpression of hsa_circ_0009361 up-regulated the expression of adenomatous polyposis coli 2 (APC2) and inhibited the activity of the Wnt/?-catenin pathway by competitively combining with miR-582. Exogenous miR-582 and APC2 interventions could reverse the multiple biological functions mediated by hsa_circ_0009361 in CRC cells. In vivo experiments also confirmed that hsa_circ_0009361 inhibited the growth and metastasis of CRC. Hsa_circ_0009361 acted as a tumor suppressive sponge of miR-582, which could up-regulate the expression of APC2, inhibit the Wnt/?-catenin signaling, and suppress the growth and metastasis of CRC.
Pubmed ID	31109967
Year	2019
Title	Hsa_circ_0009361 Acts as the Sponge of miR-582 to Suppress Colorectal Cancer Progression by Regulating APC2 Expression

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