Basic Information
| LncRNA/CircRNA Name | circ_001569 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , western blot , CCK-8 assay , colony formation assay , cell apoptosis analysis , wound healing assays , transwell invasion assay |
| Sample | BC tissues and matched normal breast tissues ,normal human breast epithelial cell line, MCF- 7810A, and human breast cancer cell lines (MCF-7, MDA-MB-468, MDAMB-231 and MDA-MB-453) |
| Expression Pattern | up-regulated |
| Function Description | We found that hsa_circ_001569 expression was significantly up-regulated in both BC tissues and cell lines. Overexpression of hsa_circ_001569 was associated with Lymph node metastasis, advanced clinical stage and shorter overall survival.Multivariate assay confirmed that hsa_circ_001569 expression was an independent prognostic factor for 5-year overall survival. Furthermore, knockdown of hsa_circ_001569 significantly suppressed the growth and metastatic potentials of BC cells. Besides, depression of hsa_circ_001569 impeded the activation of PI3K-AKT signaling in BC cells. |
| Pubmed ID | 31104012 |
| Year | 2019 |
| Title | Hsa_circ_001569 Is an Unfavorable Prognostic Factor and Promotes Cell Proliferation and Metastasis by Modulating PI3K-AKT Pathway in Breast Cancer |
External Links
| Links for circ_001569 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |