Basic Information
| LncRNA/CircRNA Name | circ_0067934 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , western blot , CCK-8 assays , cell apoptosis analysis , wound healing assays , transwell invasion assay |
| Sample | human GBM and the corresponding normal brain tissues ,GBM cell lines(LN18, U251, LN229, T98G and A172 cells),and normal human astrocytes, NHA cells |
| Expression Pattern | up-regulated |
| Function Description | The expression level of hsa_circ_0067934 was significantly increased in GBM tissues and cancer cells. Patients with higher expression of hsa_circ_0067934 had a more favorable overall survival and disease-free survival. The functional investigations revealed that the knockdown of hsa_circ_0067934 suppressed GBM cell proliferation, metastasis and EMT, and promoted apoptosis. Moreover, the mechanistic analysis demonstrated that the down-regulation of hsa_circ_0067934 significantly suppressed the activation of the PI3K-AKT pathway. |
| Pubmed ID | 31081099 |
| Year | 2019 |
| Title | Up-regulated Circular RNA hsa_circ_0067934 Contributes to Glioblastoma Progression Through Activating PI3K-AKT Pathway |
External Links
| Links for circ_0067934 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |