Basic Information
| LncRNA/CircRNA Name | circ_0005075 |
| Synonyms | circ_0005075 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR , western blot , CCK-8 , colony formation assay , cell apoptosis analysis , wound healing assays , transwell invasion assay |
| Sample | CRC tissues and matched normal colorectal tissues ,human normal intestinal epithelial cell line(HCO) and six CRC cell types (SW480, SW620,HT29, HCT116, SW1116, and LOVO) |
| Expression Pattern | up-regulated |
| Function Description | We observed that circ_0005075 expression was significantly up-regulated in both CRC tissues and cell lines. Then, clinical assays indicated that high circ_0005075 expression was significantly associated with histology/differentiation, depth of invasion, advanced TNM stage, and shorter overall survival and disease-free survival of CRC patients. Cellular studies indicated that circ_0005075 can enhance the proliferation, migration, and invasion capacities of CRC cells, thereby promoting tumor progression. Further mechanistic investigation showed that circ_0005075 displayed its tumor-promotive roles through activating Wnt/?-catenin pathway. |
| Pubmed ID | 31081084 |
| Year | 2019 |
| Title | Hsa_circ_0005075 Predicts a Poor Prognosis and Acts as an Oncogene in Colorectal Cancer via Activating Wnt/?-catenin Pathway |
External Links
| Links for circ_0005075 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |