Basic Information
| LncRNA/CircRNA Name | circ_100876 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , western blot , Dual luciferase reporter assay , cell proliferation assay , flow cytometry analyses , cell migration assay |
| Sample | Osteosarcoma and adjacent nontumor tissues ,human osteosarcoma cancer cells lines (143B, Saos??,MG??3, HOS, os??32, and U2-OS) ,normal human osteoblasts cells (hFOB1.19) |
| Expression Pattern | up-regulated |
| Function Description | The expression of circRNA_100876 was found to be significantly upregulated in osteosarcoma, and was closely correlated with the tumor size and tumor differentiation degree. In addition, the knockdown of circRNA_100876 could significantly inhibit the tumor growth, both in vitro and in vivo.Downregulation of circRNA_100876 inhibited osteosarcoma cells proliferation via promoting apoptosis and arresting more cells in the G2/M stage, as suggested by the expression of apoptosis and cell cycle pathway-related proteins, which changed consistently. Furthermore, the level of miR-136 was negatively correlated with the expression of circRNA_100876, and miR-136 inhibitors were able to reverse the suppression of cell proliferation induced by silencing circRNA_100876. |
| Pubmed ID | 31069828 |
| Year | 2019 |
| Title | Dysregulated circRNA_100876 Suppresses Proliferation of Osteosarcoma Cancer Cells by Targeting microRNA-136 |
External Links
| Links for circ_100876 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |