Basic Information
| LncRNA/CircRNA Name | circ_0005198 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Dual luciferase reporter assay , transwell assays , apoptosis assay , cell proliferation detection |
| Sample | GM tissues and their paired noncancerous tissues ,GM cell lines and normal cell line |
| Expression Pattern | up-regulated |
| Function Description | The expression of circ_0005198 was enhanced in GM tumors and cells. Its expression in tumor specimens was related to clinical severity and poor prognosis. Functionally, circ_0005198 could remarkably boost cell growth, clone-forming ability, and metastatic properties and attenuate cell apoptosis in GM cells. What's more, circ_0005198 could directly sponge miR-1294 to exert oncogenic functions. |
| Pubmed ID | 31038801 |
| Year | 2019 |
| Title | Overexpression of circ_0005198 Sponges miR-1294 to Regulate Cell Proliferation, Apoptosis, Migration, and Invasion in Glioma |
External Links
| Links for circ_0005198 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |