Basic Information
| LncRNA/CircRNA Name | circ_001350 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , luciferase reporter assay , apoptosis assays , transwell assays , cell proliferation detection |
| Sample | glioma tissues and their paired noncancerous tissues ,glioma cell lines(U87, U251, LN229, and A172) and normal cells NHA |
| Expression Pattern | up-regulated |
| Function Description | Circ_001350 level was significantly enhanced in glioma tissue specimens and cells. Further, elevated expression of circ_001350 was closely linked to patients' clinical severity. Knockdown of circ_001350 could inhibit cell proliferation and metastatic properties and increase apoptotic cells. circ_001350 could directly bind to miR-1236 and regulate its expression to exert oncogenic functions. Collectively, circ_001350 directly sponges miR-1236, thus contributing to malignant progression of glioma. |
| Pubmed ID | 31020693 |
| Year | 2019 |
| Title | Circular RNA circ_001350 Regulates Glioma Cell Proliferation, Apoptosis, and Metastatic Properties by Acting as a miRNA Sponge |
External Links
| Links for circ_001350 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |