Basic Information
| LncRNA/CircRNA Name | circRAD18 |
| Synonyms | circ_0002453 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , western blot , Dual luciferase reporter assay , RNase R treatment , actinomycin D assay , CCK8 assay , colony formation assay , EdU sssay , wound healing assay and transwell assay , in vivo tumor growth assays |
| Sample | triple negative breast cancer tissues and its adjacent noncancerous mammal tissues ,human breast cancer immortalized cell lines (MDA-MB-231,MDA-MB-468, BT549, HCC38, HCC1806, MCF-7, T47D,MDA-MB-453, BT474 and Skbr-3),normal mammary epithelial cell lines (MCF-10A) and HEK 293T cells |
| Expression Pattern | up-regulated |
| Function Description | Expression of circRAD18 was found significantly upregulated in TNBC compared with normal mammary tissues and cell lines.circRAD18 was positively correlated with T stage, clinical stage and pathological grade and was an independent risk factor for TNBC patients.Knockdown of circRAD18 significantly suppressed cell proliferation and migration, promoted cell apoptosis and inhibited tumor growth.CircRAD18 acts as a sponge of miR-208a and miR-3164 and promotes TNBC progression through upregulating IGF1 and FGF2 expression. |
| Pubmed ID | 31001629 |
| Year | 2019 |
| Title | circRAD18 Sponges miR-208a/3164 to Promote Triple-Negative Breast Cancer Progression Through Regulating IGF1 and FGF2 Expression |
External Links
| Links for circRAD18 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |