Basic Information
| LncRNA/CircRNA Name | CCAT1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000247844 |
| Refseq | NR_108049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | OSCC tissues and their adjacent noncancerous tissues ,normal human gingival fibroblasts (HGF-1) ,human OSCC cell lines (SCC-9, KB, Cal-27, SCC-25, HN6 and SCC-090) |
| Expression Pattern | up-regulated |
| Function Description | CCAT1 was upregulated in OSCC tissues and cell lines. Knockdown of CCAT1 inhibited the proliferation, migration and invasion of OSCC cells, while the cell apoptosis was enhanced.miR-181a was a direct target of CCAT1. Inhibition of miR-181a partially reversed the efficacy of sh-CCAT1.Moreover, sh-CCAT1 inhibited OSCC tissues growth through inhibiting Wnt signaling in a miR-181a-dependent manner in vivo.CCAT1 activated Wnt/?-catenin signaling via inhibiting miR-181a, resulting in the cell proliferation, migration and invasion of OSCC, suggesting that CCAT1 might serve as a potential target of OSCC treatment. |
| Pubmed ID | 31599709 |
| Year | 2019 |
| Title | Long Non-Coding RNA CCAT1 Is a Prognostic Biomarker for the Progression of Oral Squamous Cell Carcinoma via miR-181a-mediated Wnt/?-catenin Signaling Pathway |
External Links
| Links for CCAT1 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |