Basic Information
LncRNA/CircRNA Name | CCAT1 |
Synonyms | CCAT1, CARLo-5, onco-lncRNA-40 |
Region | NA |
Ensemble | ENSG00000247844 |
Refseq | NR_108049 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | ovarian cancer |
ICD-0-3 | C56.9 |
Methods | qPCR, Western blot, Luciferase reporter assay, other |
Sample | Ovarian cancer tissues and cell lines (SKOV3 and CaOV3) |
Expression Pattern | up-regulated |
Function Description | And CCAT1 knockdown decreased cell migration, invasion and EMT-associated markers expression of ovarian cancer cells treated with TGF?1. CCAT1 directly targeted and downregulated miR-490-3p, then increasing TGF?R1 level. miR-490-3p was shown to regulate cell invasion, migration and EMT markers expression via TGF?R1. In addition, we also observed that miR-490-3p was essential for TGF?1-induced tumor cell invasion and migration influenced by CCAT1. CCAT1 level was significantly higher in tumors than adjacent normal tissue, in contrast, miR-490-3p level was lower in ovarian tumors. |
Pubmed ID | 30250403 |
Year | 2018 |
Title | The lncRNA CCAT1 Upregulates TGF?R1 via Sponging miR-490-3p to Promote TGF?1-induced EMT of Ovarian Cancer Cells |
External Links
Links for CCAT1 | GenBank HGNC NONCODE |
Links for ovarian cancer | OMIM COSMIC |