Basic Information
| LncRNA/CircRNA Name | CCAT1 |
| Synonyms | CCAT1, CARLo-5, onco-lncRNA-40 |
| Region | NA |
| Ensemble | ENSG00000247844 |
| Refseq | NR_108049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, other |
| Sample | Ovarian cancer tissues and cell lines (SKOV3 and CaOV3) |
| Expression Pattern | up-regulated |
| Function Description | And CCAT1 knockdown decreased cell migration, invasion and EMT-associated markers expression of ovarian cancer cells treated with TGF?1. CCAT1 directly targeted and downregulated miR-490-3p, then increasing TGF?R1 level. miR-490-3p was shown to regulate cell invasion, migration and EMT markers expression via TGF?R1. In addition, we also observed that miR-490-3p was essential for TGF?1-induced tumor cell invasion and migration influenced by CCAT1. CCAT1 level was significantly higher in tumors than adjacent normal tissue, in contrast, miR-490-3p level was lower in ovarian tumors. |
| Pubmed ID | 30250403 |
| Year | 2018 |
| Title | The lncRNA CCAT1 Upregulates TGF?R1 via Sponging miR-490-3p to Promote TGF?1-induced EMT of Ovarian Cancer Cells |
External Links
| Links for CCAT1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |