Basic Information
| LncRNA/CircRNA Name | circLARP4 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR, FISH, Cell proliferation assays and cell cycle analysis, Western blotting and immunohistochemistry analysis, RIP, Luciferase reporter assay, Animal experiment |
| Sample | HCC tissues, normal human liver cell line QSG-7701 and HCC cell lines Huh7, Hep3B, SMMC7721, HepG2, MHCC97L and HCCLM3 |
| Expression Pattern | down-regulated |
| Function Description | Downregulated circLARP4 level was observed in HCC tissues and cell lines. Low expression level of circLARP4 independently predicted poor survival outcome. Gain-of-function and loss-of-function assays demonstrated that circLARP4 suppressed HCC cell proliferation, mediated cell cycle arrest and induced senescence in vitro. Levels of p53 and p21, 2 key regulatory molecules in cellular senescence, were increased in circLARP4-overexpressed HCC cells and decreased in circLARP4- silenced HCC cells. In vivo experiments further confirmed the tumor-suppressing activity of circLARP4. Further mechanistic studies showed that circLARP4 dampened HCC progression by sponging miR-761, thereby promoting the expression level of RUNX3 and activating the downstream p53/p21 signaling. |
| Pubmed ID | 30520539 |
| Year | 2018 |
| Title | circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma |
External Links
| Links for circLARP4 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |