Basic Information
| LncRNA/CircRNA Name | circVRK1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, CCK-8 assay, Radiosensitivity assay, Transwell assay, Western blot, Immunofluorescence, RIP, Luciferase reporter assay |
| Sample | ESCC tumor tissues, ESCC cells lines (KYSE150, KYSE450, EC109 and EC9706) and one normal human esophageal cell line (Het-1A) |
| Expression Pattern | down-regulated |
| Function Description | circVRK1 was downregulated in ESCC tissues and cell lines.?Functionally, overexpression of circVRK1 suppressed the cell proliferation, migration and epithelial-mesenchymal transition (EMT) and reversed the radioresistance.?Therefore, we identified the tumor suppressive role of circVRK1 in ESCC progression.?Mechanistically, circVRK1 positively regulated PTEN by acting as a molecular sponge of miR-624-3p.?Moreover, circVRK1 decreased the activity of PI3K/AKT signaling pathway by upregulating PTEN.?Our findings showed that circVRK1 suppressed ESCC progression by regulating miR-624-3p/PTEN axis and PI3K/AKT signaling pathway |
| Pubmed ID | 30508543 |
| Year | 2018 |
| Title | CircVRK1 regulates tumor progression and radioresistance in esophageal squamous cell carcinoma by regulating miR-624-3p/PTEN/PI3K/AKT signaling pathway |
External Links
| Links for circVRK1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |