Basic Information
| LncRNA/CircRNA Name | circ_0005230 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, Colony forming assay, Flow cytometric analysis, Transwell assay, Dual luciferase reporter assay, Immunoblotting assay, Animal study |
| Sample | BC tissues, BC cells (MCF7, SKBR3, BT-20, T47D, MDA-MB-231, MDA-MB-436) and one normal mammary epithelial cell line (MCF10A) |
| Expression Pattern | up-regulated |
| Function Description | circ_0005230 was overexpressed in BC tissue specimens and cell lines. The overexpression of circ_0005230 was related to adverse phenotypes in the patients with BC. In addition, circ_0005230 could be regarded as a prognostic predictor in BC patients. In vitro and in vivo data demonstrated the cell growth promoting role of circ_0005230. Moreover, circ_0005230 could also promote cell migratory and invasive capacities. For the mechanism investigation, circ_0005230 was proved to be a sponge of miR-618, and expression of miR-618 could regulate CBX8 expression via targeting the 3 UTR of CBX8. Rescue assays also illustrated an oncogenic function of circ_0005230 in BC via acting as a miR-618 sponge to promote CBX8 expression. |
| Pubmed ID | 30504704 |
| Year | 2018 |
| Title | Increased Expression of Circular RNA circ_0005230 Indicates Dismal Prognosis in Breast Cancer and Regulates Cell Proliferation and Invasion via miR-618/CBX8 Signal Pathway |
External Links
| Links for circ_0005230 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |