Basic Information
| LncRNA/CircRNA Name | circITCH |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, CCK-8, Transwell migration and invasion assay, Luciferase reporter assay, Western blot, Immunohistochemistry, Animal studies |
| Sample | breast cancer (Luminal A, Luminal B, HER-2 +, TNBC) tissues, cell lines MCF-10A, MCF-7, T47D, SK-BR-3, MDA-MB-231 and BT-549 |
| Expression Pattern | down-regulated |
| Function Description | In this study, we characterized the role of circ-ITCH in TNBC and found that circ-ITCH was significantly down-regulated in TNBC tissues and cell lines and closely associated with poor prognosis. We therefore constructed the MDA-MB-231 and BT-549 TNBC cell lines stably expressing circ-ITCH by lentiviral vectors to determine its underlying mechanisms in TNBC progression. Most importantly, over-expression of circ-ITCH remarkably inhibited TNBC proliferation, invasion and metastasis both in vitro and in vivo. Mechanistically, we found that circ-ITCH acts as a sponge for miR-214 and miR-17 to increase expression of its ITCH linear isoform, thereby inactivating Wnt/ -catenin signaling. |
| Pubmed ID | 30509108 |
| Year | 2018 |
| Title | Circ-ITCH regulates triple-negative breast cancer progression through the Wnt/ -catenin pathway |
External Links
| Links for circITCH | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |