Basic Information
| LncRNA/CircRNA Name | circFNDC3B |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | Actinomycin D assay, Fluorescence in situ hybridization, RNase R treatment, qRT-PCR, Cell proliferation assay, Cell migration and invasion assays, Biotin-labeled probe pull-down assay, Biotin-labeled miRNA capture, Dual luciferase reporter assay, Western blot analysis, HE and immunohistochemistry, Animal experiments |
| Sample | BC tissues, invasive BC cell lines T24 and UM-UC-3, and the human immortalized uroepithelium cell line SV-HUC-1 |
| Expression Pattern | down-regulated |
| Function Description | circFNDC3B was dramatically downregulated in BC tissues and correlated with pathological T stage, grade, lymphatic invasion and patients overall survival rate. Functionally, overexpression of circFNDC3B significantly inhibited proliferation, migration and invasion both in vitro and in vivo. Mechanistically, circFNDC3B could directly bind to miR-1178-3p, which targeted the 5 UTR of the oncogene G3BP2. Moreover, circFNDC3B acted as a miR-1178-3p sponge to suppress G3BP2, thereby inhibiting the downstream SRC/FAK signaling pathway. |
| Pubmed ID | 30458784 |
| Year | 2018 |
| Title | Invasion-related circular RNA circFNDC3B inhibits bladder cancer progression through the miR-1178-3p/G3BP2/SRC/FAK axis |
External Links
| Links for circFNDC3B | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |