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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	gastric cancer
ICD-0-3	C16
Methods	qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc.
Sample	GC tissues, GC cell lines (MKN45, Hs746T, SGC-7901) and gastric epithelial cell line GES-1
Expression Pattern	up-regulated
Function Description	The results exhibited the fact that CCAT1 was expressed higher in 57 GC tissue samples than in 57 paired adjacent normal tissue samples. The expression of CCAT1 was also increased in GC cell lines (MKN45, Hs746T, and SGC 7901) compared with the gastric epithelial cell line GES 1. Besides this, decreased cell proliferation with increased cell apoptosis was detected in SGC 7902 cells transfected with CCAT1 short hairpin RNA (shRNA). At the same time, a lower cell invasion ability was measured in SCG 7901 cells transfected with CCAT1 shRNA. In addition, miR 219 1 was predicted and convinced a direct target of CCAT1. The expression of miR 219 1 was decreased in GC tissues and GC cell lines. Further studies demonstrated that the roles of CCAT1 in cell proliferation, apoptosis, and invasion were inhibited by miR 219 1. Finally, in vivo experiment indicated that tumor growth of GC was suppressed through knockdown of CCAT1. In conclusion, these results suggested that CAT1 promotes the tumorigenesis and progression of GC by negatively regulating miR 219 1
Pubmed ID	31478245
Year	2019
Title	lncRNA CCAT1 contributes to the growth and invasion of gastric cancer via targeting miR-219-1

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