Basic Information
| LncRNA/CircRNA Name | circABCB10 |
| Synonyms | circ_0008717 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | CCK8, Transwell migration assays, Luciferase reporter assay, Xenografts in mice, qRT??CR, Western blot analysis |
| Sample | Breast cancer cell lines (A549, H1975, PC9, H1299, and H1650) and normal human lung epithelial cells (BEAS??B) |
| Expression Pattern | up-regulated |
| Function Description | the expression of circABCB10 in NSCLC cell lines was increased.?Downregulation of circABCB10 suppressed NSCLC cell proliferation and migration by promoting microRNA miR 1252 expression and suppressing Forkhead box 2 (FOXR2).?Fluorescein reporting experiments confirmed that circABCB10 expression increased FOXR2 levels by sponging miR 1252, and in vivo experiments found that knockdown of circABCB10 decreased tumor growth. |
| Pubmed ID | 30417418 |
| Year | 2018 |
| Title | CircABCB10 promotes nonsmall cell lung cancer cell proliferation and migration by regulating the miR??252/FOXR2 axis |
External Links
| Links for circABCB10 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |