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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating	exosome
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	gastric cancer
ICD-0-3	C16
Methods	Transmission electron microscopy assay, Nanoparticle Tracking Analysis, qRT-PCR, Northern blotting analysis, FISH, Immuno-precipitation, Western blotting, Oil red O staining, Luciferase assay, Immunohistochemistry, H&E staining
Sample	GC tissues, gastric adenocarcinoma cell SGC7901, HEK293T and 3T3L1
Expression Pattern	up-regulated
Function Description	A group of exosomal circRNAs are upregulated in the plasma of GC patients, and one circRNA (hsa_circ_0010522) was named ciRS-133 (circular RNA sponge for miR-133) for its potential interaction with miR-133.?Moreover, plasma exosomal ciRS-133 was positively correlated with BAT levels.?An in vivo study demonstrated that exosomes from GC cells enhance PRDM16 expression and activate UCP1 in pre-adipocytes and accelerate the metabolic rate of mature adipose cells.?The exosome-delivered ciRS-133 regulates this process by absorbing miR-133 and up-regulating PRDM16.?By analyzing oxygen consumption, heat production and the mass and morphology of adipose tissues in mice, we showed that knockdown of ciRS-133 in cancer cells significantly reduces metabolic disorder caused by gastric tumors.?Hence, secreted onco-circRNA delivered by exosomes plays a key role in aggravating tumor cachexia by regulating WAT browning.
Pubmed ID	30412280
Year	2018
Title	Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway

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